CLIMBING FIBER PURKINJE CELL TWINS ARE FOUND

Witali L. Dunin-Barkowski 1,2*, Sergey N. Markin 2, Lubov N. Podladchikova 2,
Donald C. Wunsch 1

1Applied Computational Intelligence Laboratory,
Texas Tech University, Lubbock, 79409-3102 TX, USA,
http://www.acil.ttu.edu

2 A.B. Kogan Research Institute for Neurocybernetics,
Rostov-on-Don, Russia

* Visiting from Information Transmission Problems Institute,
Russian Academy of Science, Moscow,


Abstract

At the IJCNN'93 in Nagoya we have pronounced a challenging goal: to get activity patterns of pairs of Purkinje cells (PC), controlled with the same climbing fiber (CF), - a CF PC Twins problem [2]. Here, for the first time in cerebellar studies, CF PC twins have been identified and studied. Several important features of the CF PC twins activity are demonstrated: (1) High constancy of conduction time of impulses of cells of inferior olives to the targeted PCs, (2) A relatively high failure rate (0.05 - 0.18) of impulse propagation into terminal branches of CF, (3) A salient difference in complex spikes (CS) - simple spikes (SS) interaction between the PC twins, (4) SS cross-correlation between twin cells is zero, thus contradicting a nave prediction of several cerebellar learning theories.

[Full paper]



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